During this project you will study events taking place during activation of the immune system. The project will combine studies on immune responses to defined nanoscale ligand patterns with the use of Single-cell RNA sequencing. Sequencing by Drop-seq allows analyses of gene expression in thousands of individual cells in a single experiment; in this project primarily B-cells will be the main cell of interest. The project will focus on the characterization of immune responses following exposure of the immune system to model antigens. The antigens in question will be generated using nanotechnologies with specific patterning of B-cell ligands. The experiments will involve in vitro experiments on presentation of such patterns to transgenic or knock-in B-cells combined with in vivo studies, including but not limited to the B1-8/NP system.
Applicants seeking further information are invited to contact:
Søren E. Degn, Department of Biomedicine, Aarhus University, firstname.lastname@example.org , Mobile: +4522141703 or Steffen Thiel, Department of Biomedicine, Aarhus University, email@example.com , Mobile: +4529270890
Application deadline by April 1st 2018