On Monday, December 9th, Søren Degn will host a seminar given by Valentyn Oksenych, PhD,
group leader at Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
The title of this I&I International Seminar is:
“New factors required for lymphocyte development: in vivo models”
Venue: Merete Barker Auditorium, (Bldg. 1253-211 / Lake side lecture theatres)
Development of B and T lymphocytes depends on the DNA breaks and repair events known as V(D)J recombination. There are two molecular pathways involved in the DNA repair during the lymphocyte development, non-homologous end joining (NHEJ) and DNA damage response (DDR). Recently, new accessory NHEJ factors PAXX and Mri were reported. Deficiency for PAXX or Mri, however, had no obvious effect on the lymphocyte development. Applying genetic models, we found that PAXX and Mri are functionally redundant with another NHEJ factor, XLF. Moreover, combined deficiency for XLF/PAXX and XLF/Mri results in dramatic, although distinct, phenotypes. In addition, we found that multiple factors from the DDR pathway are required for specific stages of B cell development.