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Novel mechanisms in innate immune defense against virus infections – Søren Riis Paludan – DTU
22. November 2023 @ 1:00 pm - 2:30 pm
Synopsis: Pattern recognition receptors (PRRs) are broadly perceived to constitute the first line of defense against infections. While PRRs indeed evoke strong antimicrobial activity, these immune receptors also induce inflammation and are frequently associated with pathologies. This raises the question as to whether additional early immune mechanisms exist, which are less inflammatory and operate independently of PRRs. Interestingly, emerging data from us and others suggest that a panel constitutive and stress-induced immune mechanisms do indeed exert host defense independently of PRRs – and often in a non-redundant manner. These data challenge the current thinking in immunology. In this talk, I will present recent data on novel immune mechanisms in antiviral defense, and will discuss how such data may fit into the larger scheme of how the immune system ensures efficient early host defense without causing pathological inflammatory responses.
Time: November 22nd at 13:00
Location: DTU, building 101 room Ly101-R3.086 S01
About the speaker:
Søren Riis Paludan is a professor at the Department of Biomedicine at , Denmark, where his research is focused on understanding how the immune system is activated during viral infections and how the immune system can contribute to both defense and disease development (Paludan lab). He has identified novel mechanisms of defense against virus infections and in 2021 he received a Lundbeck Foundation Professorships research grant to study these novel mechanisms in the brain. From this year he is also leader of the Danish National Research Foundation Center of excellence Center of Immunology of Viral infections (https://biomed.au.dk/civia).
Links to latest publications from 2023:
TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain