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DTSTART;TZID=Europe/Copenhagen:20241125T133000
DTEND;TZID=Europe/Copenhagen:20241125T150000
DTSTAMP:20260815T174359
CREATED:20241104T074940Z
LAST-MODIFIED:20241104T085206Z
UID:6198-1732541400-1732546800@immunologisk-selskab.dk
SUMMARY:Trained immunity: a memory for innate host defense - Mihai Netea
DESCRIPTION:Mihai Netea \nInvited speaker to DTU on November 25th at 13:30\nLocation: Ly101-R3.086 meeting room S01 \nMihai Netea was born and studied medicine in Cluj-Napoca\, Romania. He completed his PhD at the Radboud University Nijmegen\, The Netherlands\, on studies investigating the cytokine network in sepsis. After working as a post-doc at the University of Colorado\, he returned to Nijmegen where he finished his clinical training as an infectious disease specialist\, and where he currently heads the division of Experimental Medicine\, Department of Internal Medicine\, Nijmegen University Nijmegen Medical Center. His main research interests are pattern recognition of fungal pathogens and the induction of antifungal immunity\, primary immunodeficiencies in innate immune system\, and the study of the memory traits of innate immunity. \nTrained immunity: a memory for innate host defense\nThe inability of innate immunity to build an immunological memory\, considered one of the main characteristics differentiating it from adaptive immunity\, has been recently challenged by studies in plants\, invertebrates\, and mammals. Long-term reprogramming of innate immunity\, that induces adaptive traits and has been termed trained immunity characterizes prototypical innate immune cells such as natural killer cells and monocytes\, and provides protection against reinfection in a T/B-cell-independent manner. In contrast\, trained immunity has been shown to be able to induce protection against reinfection in a lymphocyte-independent manner. Non-specific protective effects dependent on trained immunity have also been shown to be induced after BCG vaccination in humans. Complex immunological and metabolic circuits link cell stimulation to long-term epigenetic reprogramming of the function of myeloid cells and their bone marrow progenitors. Several clinical studies have also shown immunological and clinical effects of trained immunity-inducing ligands in various diseases. \nLink to publications \nFind vej: https://maps.app.goo.gl/nuUptJCgcsBLLZBRA
URL:https://immunologisk-selskab.dk/calendar/trained-immunity-a-memory-for-innate-host-defense-mihai-netea/
LOCATION:DTU Ly101-R3.086 Room S01\, Anker Engelunds Vej 1\, Kongens Lyngby\, 2800\, Denmark
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20241114T120000
DTEND;TZID=Europe/Copenhagen:20241114T203000
DTSTAMP:20260815T174359
CREATED:20241104T075553Z
LAST-MODIFIED:20241104T075553Z
UID:6200-1731585600-1731616200@immunologisk-selskab.dk
SUMMARY:AIS10 - Aarhus Immunotherapy Symposium\, 10th Anniversary Meeting
DESCRIPTION:A Decade of Discovery: Celebrating Collaboration at\nthe 10th Aarhus Immunotherapy Symposium (AIS)\nThursday 14 November 2024\nAula\, Aarhus University \n12:00-13:00 Registration\n13:00-13:05 Welcome by the Vice-Dean for Research\, Faculty of Health\, Per Höllsberg\nSession 1: Chair Thomas Vorup-Jensen & Poul Sørensen\n13:05-13:50 Paul Peter Tak\, Candel Therapeutics\, Boston\, US (Keynote): Off-the-shelf product\,\nindividualized anti-tumor immune response: Reprogramming the immune system by viral\nimmunotherapy for the treatment of solid tumors\n13:50-14:40 Johanne Tracey Jacobsen\, Oslo University\, NO: Germinal center guided design of\ntherapeutic monoclonal antibodies\n14:15:10 Sophia Karagiannis\, Epsilogen & King’s College\, UK: AllergoOncology – IgE immunotherapy\nto activate immune responses against solid tumours\n15:10-15:30 Break\nSession 2: Chair Hans Jürgen Hoffmann & Poul Sørensen\n15:30-16:00 Petra Bacher\, Universitätsklinikum Schleswig-Holstein\, Kiel\, DE: T cell mechanisms in\nAutoimmunity & Allergy\n16:00-16:30 Nick Laursen\, Commit Biologics\, DK: An antibody platform to potentiate complement\nactivation for the treatment of cancer and autoimmune diseases\n16:30-17:00 Inge Marie Svane\, Herlev University Hospital\, DK: Reaching beyond checkpoint\ninhibitors to defeat cancer by immunotherapy\n17:00-17:30 Break\nSession 3: Chair Martin K. Thomsen & Søren E. Degn\n17:30-18:00 Johannes Sam\, Roche\, Basel\, CH: CD20 T cell bispecs and CD19 costimulators for B cell\nmalignancies\n18:00-18:30 Nicola Ferrari\, AstraZeneca\, UK: CAR-T in autoimmune disease\n18:30-19:00 Eric Vivier\, Innate Pharma\, FR: Harnessing innate immunity in cancer therapy and\nbeyond\n19:00-20:00 Cocktail Dînatoire \nSign up here
URL:https://immunologisk-selskab.dk/calendar/ais10-aarhus-immunotherapy-symposium-10th-anniversary-meeting/
LOCATION:Aula\, Nordre Ringgade 4\, Aarhus C\, 8000\, Denmark
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20240415T080000
DTEND;TZID=Europe/Copenhagen:20240417T170000
DTSTAMP:20260815T174359
CREATED:20231113T082624Z
LAST-MODIFIED:20231113T082734Z
UID:6112-1713168000-1713373200@immunologisk-selskab.dk
SUMMARY:Springtime School programme - LEO Foundation Skin Immunology Research Center
DESCRIPTION:The programme for the LEO Foundation Skin Immunology Research Center Springtime School in April 2024 taking place in Hornbæk\, Denmark\, is now available. \nFor more information click here: 02 SIC springschool program 2024. \nRegistration opens on the 1st of December.
URL:https://immunologisk-selskab.dk/calendar/springtime-school-programme-leo-foundation-skin-immunology-research-center/
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20231201T140000
DTEND;TZID=Europe/Copenhagen:20231201T160000
DTSTAMP:20260815T174359
CREATED:20231129T082142Z
LAST-MODIFIED:20231129T082142Z
UID:6116-1701439200-1701446400@immunologisk-selskab.dk
SUMMARY:Pathogens\, Diet\, and Tissue Microenvironment: A Dynamic Interplay in Regeneration and Carcinogenesis
DESCRIPTION:Cindrilla Chumduri inaugural lecture. \nCindrilla Chumduri specializes in the study of infection\, carcinogenesis\, and regeneration. Her research is focused on the intricate connections that exist between the host tissue microenvironment\, diet and pathogens during the early stages of cancer development. Her work is at the forefront of developing and using patient-derived 3D organoids and in-vivo models to understand the interplay between hostpathogen interactions\, immune responses\, tissue homeostasis mechanisms\, and disease progression. Using cutting-edge technologies like advanced microscopy\, single-cell omics\, and spatial analysis\, Cindrilla and her interdisciplinary team are working to understand disease mechanisms and to identify biomarkers and therapeutic targets that will benefit early detection and treatment of diseases. \nFor more information: Inaugural_Lecture_Chumduri
URL:https://immunologisk-selskab.dk/calendar/pathogens-diet-and-tissue-microenvironment-a-dynamic-interplay-in-regeneration-and-carcinogenesis/
LOCATION:Gustav Wieds vej\, Gustav Wieds Vej 10c\, Room 3130-303\, Aarhus C\, na\, 8000\, Denmark
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20231122T130000
DTEND;TZID=Europe/Copenhagen:20231122T143000
DTSTAMP:20260815T174359
CREATED:20230926T081249Z
LAST-MODIFIED:20230926T081444Z
UID:6089-1700658000-1700663400@immunologisk-selskab.dk
SUMMARY:Novel mechanisms in innate immune defense against virus infections - Søren Riis Paludan - DTU
DESCRIPTION:Synopsis: Pattern recognition receptors (PRRs) are broadly perceived to constitute the first line of defense against infections. While PRRs indeed evoke strong antimicrobial activity\, these immune receptors also induce inflammation and are frequently associated with pathologies. This raises the question as to whether additional early immune mechanisms exist\, which are less inflammatory and operate independently of PRRs. Interestingly\, emerging data from us and others suggest that a panel constitutive and stress-induced immune mechanisms do indeed exert host defense independently of PRRs – and often in a non-redundant manner. These data challenge the current thinking in immunology. In this talk\, I will present recent data on novel immune mechanisms in antiviral defense\, and will discuss how such data may fit into the larger scheme of how the immune system ensures efficient early host defense without causing pathological inflammatory responses. \nTime: November 22nd at 13:00 \nLocation: DTU\, building 101 room Ly101-R3.086 S01 \nAbout the speaker: \nSøren Riis Paludan is a professor at the Department of Biomedicine at \, Denmark\, where his research is focused on understanding how the immune system is activated during viral infections and how the immune system can contribute to both defense and disease development (Paludan lab). He has identified novel mechanisms of defense against virus infections and in 2021 he received a Lundbeck Foundation Professorships research grant to study these novel mechanisms in the brain. From this year he is also leader of the Danish National Research Foundation Center of excellence Center of Immunology of Viral infections (https://biomed.au.dk/civia). \n  \nLinks to latest publications from 2023: \nER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 \n  \nTREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain
URL:https://immunologisk-selskab.dk/calendar/novel-mechanisms-in-innate-immune-defense-against-virus-infections-soren-riis-paludan-dtu/
LOCATION:DTU Lyngby\, Anker Engelunds Vej 1\, Kgs. Lyngby\, 2800\, Denmark
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20231013T130000
DTEND;TZID=Europe/Copenhagen:20231013T160000
DTSTAMP:20260815T174359
CREATED:20231011T180413Z
LAST-MODIFIED:20231011T180413Z
UID:6097-1697202000-1697212800@immunologisk-selskab.dk
SUMMARY:PhD defence: Isabella Skandorff Pedersen
DESCRIPTION:Exploring Endogenous GammaretroviralImmunogenicity & Cancer Vaccine Potential \nAssessment Committee:\nAssociate professor Lea Klingenberg Barfod (Chairperson)\nDr Anders Elm Pedersen\nProfessor Martin Bachmann \nSupervisors:\nClinical Professor Eivind Per Thor Straten\nAssociate Professor Peter Johannes Holst \nDepartment:\nDepartment of Immunology and Microbiology \nGraduate Programme:\nImmunology and Infectious Diseases \nPlace:\nAuditoriet 29.01.30\, Mini 1\, Panum\, Blegdamsvej 3B\, 2200\, København \nAsk for a copy of the thesis: isaskandorff@sund.ku.dk
URL:https://immunologisk-selskab.dk/calendar/phd-defence-isabella-skandorff-pedersen/
LOCATION:Panum Aud. 29.01.30\, Blegdamsvej 3B\, København N\, 2200\, Denmark
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20231013T110000
DTEND;TZID=Europe/Copenhagen:20231013T120000
DTSTAMP:20260815T174359
CREATED:20231011T180053Z
LAST-MODIFIED:20231011T180053Z
UID:6094-1697194800-1697198400@immunologisk-selskab.dk
SUMMARY:Global Excellence Research seminar XXXII - Martin Bachman - Panum
DESCRIPTION:Martin Bachmann (University of Bern)\nMartin will talk about “Virus-like particles for the development of therapeutic vaccines”. \nAdd this event to your calendar.
URL:https://immunologisk-selskab.dk/calendar/global-excellence-research-seminar-xxxii-martin-bachman-panum/
LOCATION:Panum 16.6.16 (Faculty Club)\, Blegdamsvej 3B\, København N\, 2200\, Denmark
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20230628T140000
DTEND;TZID=Europe/Copenhagen:20230628T150000
DTSTAMP:20260815T174359
CREATED:20230609T105237Z
LAST-MODIFIED:20230609T105237Z
UID:6070-1687960800-1687964400@immunologisk-selskab.dk
SUMMARY:Lecture by Graham Pawelec - "Immunosenescence: How worried should we be and when?"
DESCRIPTION:Lecture by Graham Pawelec on Immunosenescence at Panum Mærsk Tower. Please click here for more information: Seminar_Graham Pawelec_June_28
URL:https://immunologisk-selskab.dk/calendar/lecture-by-graham-pawelec-immunosenescence-how-worried-should-we-be-and-when/
LOCATION:Mærsk Tower
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20230530T113000
DTEND;TZID=Europe/Copenhagen:20230530T200000
DTSTAMP:20260815T174359
CREATED:20230224T080345Z
LAST-MODIFIED:20230224T080345Z
UID:6042-1685446200-1685476800@immunologisk-selskab.dk
SUMMARY:2023 Annual Meeting and General Assembly in DIS
DESCRIPTION:On behalf of DIS President Allan Randrup Thomsen and his co-organizers\, we are happy to invite you for the DIS Annual Meeting\, which will be held Tuesday the 30th of May\, 2023\, at Maersk Tower in Copenhagen. Please see the DIS-meeting-Invitation_2023 for programme and use the DIS-Meeting-Registration_2023 for signup and abstract submission as indicated in the invitation.\n\nThe deadline for registration and abstract submission is May 1st\, 2023\, but space is limited and allocated on a first come\, first served basis\, so sign up at your earliest convenience!\n\nThe general assembly will be held at the meeting\, from 14.30 – 15.15 and is open to all society members\, whether you participate in the meeting or not.\n\nMembers who wish to suggest items for the agenda for the General Assembly should submit these to the society secretary no later than 14 days before the meeting\, i.e.\, the 16th of March the latest.\n\nWe look forward to seeing you in Copenhagen!
URL:https://immunologisk-selskab.dk/calendar/2023-annual-meeting-and-general-assembly-in-dis/
LOCATION:Mærsk Tower
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20221124T133000
DTEND;TZID=Europe/Copenhagen:20221124T200000
DTSTAMP:20260815T174359
CREATED:20221107T201930Z
LAST-MODIFIED:20221107T201958Z
UID:6016-1669296600-1669320000@immunologisk-selskab.dk
SUMMARY:8. Aarhus Immunotherapy Symposium (AIS8)
DESCRIPTION:Join us for the 8th Aarhus Immunotherapy Symposium: “Immunotherapy in the service of medicine”. See program here: AIS8_3rd Call_A4
URL:https://immunologisk-selskab.dk/calendar/8-aarhus-immunotherapy-symposium-ais8/
LOCATION:Aula\, Nordre Ringgade 4\, Aarhus C\, 8000\, Denmark
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20220321T080000
DTEND;TZID=Europe/Copenhagen:20220321T170000
DTSTAMP:20260815T174359
CREATED:20220321T111423Z
LAST-MODIFIED:20220321T111423Z
UID:5941-1647849600-1647882000@immunologisk-selskab.dk
SUMMARY:Annual Meeting of the Danish Immunology Society - Aarhus May 25\, 2022
DESCRIPTION:Dear Members and Guests\, \nIt is with great pleasure that we invite you to join us for the Annual Meeting of the Danish Immunology Society. \nDate: Wednesday the 25th of May\, 2022. \nPlace: Aarhus University\, Department of Molecular Biology and Genetics\, Universitetsbyen 81\, Building 1870\, Aud. 120 (scientific talks and general assembly)\, Foyer (exhibitor stalls and coffee breaks)\, and the Kantine (lunch\, posters and dinner). \nAbstract submission and registration deadline: Wednesday April 20\, 2022 \nFor more information: DIS Meeting – Program Tentative
URL:https://immunologisk-selskab.dk/calendar/annual-meeting-of-the-danish-immunology-society-aarhus-may-25-2022/
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20211125T130000
DTEND;TZID=Europe/Copenhagen:20211125T200000
DTSTAMP:20260815T174359
CREATED:20211108T104814Z
LAST-MODIFIED:20211112T091211Z
UID:5914-1637845200-1637870400@immunologisk-selskab.dk
SUMMARY:7th Aarhus Immunotherapy Symposium (AIS7)
DESCRIPTION:Looking to the future of immunotherapies  \nThursday November 25th\, 1:00-8:00 PM  \nAulaen (Bldg. 1412)\, Ndr. Ringgade\, Aarhus University  \nFor more information\, and to sign up for this event\, please click here: AIS7; FINAL PROGRAM_rev3
URL:https://immunologisk-selskab.dk/calendar/7th-aarhus-immunotherapy-symposium-ais7/
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20210823T103000
DTEND;TZID=Europe/Copenhagen:20210823T200000
DTSTAMP:20260815T174359
CREATED:20210519T094247Z
LAST-MODIFIED:20210811T071328Z
UID:5868-1629714600-1629748800@immunologisk-selskab.dk
SUMMARY:Danish Immunology Society Annual Meeting\, August 23rd\, 2021!
DESCRIPTION:Dear Members and Guests\, \nIt is with great pleasure that we invite you to join us for the Annual Meeting of the Danish Immunology Society at SDU in Odense. Please see the final program here: DIS Annual Meeting-2021 \nThe registration form can be found here: DIS-Meeting-Registration_2021 upd
URL:https://immunologisk-selskab.dk/calendar/danish-immunology-society-annual-meeting-august-23rd-2021/
LOCATION:SDU\, J. B. Winsløws Vej 25\, Odense\, 5000
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20210624
DTEND;VALUE=DATE:20210626
DTSTAMP:20260815T174359
CREATED:20190926T080931Z
LAST-MODIFIED:20210322T092642Z
UID:5635-1624492800-1624665599@immunologisk-selskab.dk
SUMMARY:34th Annual Meeting for The European Macrophage and Dendritic cell Society - EMDS2021
DESCRIPTION:Virtual event\, June 24-25th \nThis meeting aims to bring together scientists in macrophage/dendritic cell research with adjoining fields of such as transcriptomics\, infectious disease\, and structural biology\, to present and discuss cutting edge research in this broadening field. A key goal of the meeting is to promote communication between world class scientists and a young generation of researchers\, ranging from molecular immunologists to clinical scientists\, and thus to facilitate the translation of new basic discoveries. \nABSTRACT SUBMISSION CLOSES APRIL 30TH 2021 \nREGISTRATION CLOSES MAY 31ST 2021 \nFor more information\, click here.
URL:https://immunologisk-selskab.dk/calendar/34th-annual-meeting-for-the-european-macrophage-and-dendritic-cell-society-emds2020/
LOCATION:Online\, Denmark
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20210503
DTEND;VALUE=DATE:20210522
DTSTAMP:20260815T174359
CREATED:20210213T112156Z
LAST-MODIFIED:20210322T094540Z
UID:5752-1620000000-1621641599@immunologisk-selskab.dk
SUMMARY:Pasteur Course - INNATE IMMUNITY and INFECTIOUS DISEASES
DESCRIPTION:This two and half week long course offers lectures on the players and on the mechanisms of the innate immune system and inflammation involved in the defense of the host against pathogens. It also offers lectures on the new tools allowing to study the immune system. \nFor more info click here.
URL:https://immunologisk-selskab.dk/calendar/pasteur-course-innate-immunity-and-infectious-diseases/
LOCATION:Online\, Denmark
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20210325T130000
DTEND;TZID=Europe/Copenhagen:20210325T150000
DTSTAMP:20260815T174359
CREATED:20210319T122217Z
LAST-MODIFIED:20210322T094611Z
UID:5847-1616677200-1616684400@immunologisk-selskab.dk
SUMMARY:PhD defence - VACCINE-RELEVANT INSIGHTS INTO HEPATITIS C VIRUS EVASION FROM BROADLY NEUTRALIZING ANTIBODIES
DESCRIPTION: ELIAS HONERØD AUGESTAD will defend his PhD on the 25th of March 2021 at 1 PM (Central European Time) . The defence will take place online. For more information click here: INVITATION PHD DEFENSE_Elias Honerød Augestad_25 March 2021
URL:https://immunologisk-selskab.dk/calendar/phd-defence-vaccine-relevant-insights-into-hepatitis-c-virus-evasion-from-broadly-neutralizing-antibodies/
LOCATION:Online\, Denmark
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20201126T150000
DTEND;TZID=Europe/Copenhagen:20201126T183000
DTSTAMP:20260815T174359
CREATED:20201109T074908Z
LAST-MODIFIED:20201117T161706Z
UID:5718-1606402800-1606415400@immunologisk-selskab.dk
SUMMARY:6th Aarhus Immunotherapy Symposium (AIS6)
DESCRIPTION:New insights and therapies for immunological diseases\nThursday November 26th\, 3:00-6:30 PM CET\nWebinar \nFor more info and to sign up\, click this link.
URL:https://immunologisk-selskab.dk/calendar/6th-aarhus-immunotherapy-symposium-ais6/
CATEGORIES:News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20200219
DTEND;VALUE=DATE:20200222
DTSTAMP:20260815T174359
CREATED:20190608T154454Z
LAST-MODIFIED:20191206T075458Z
UID:5599-1582070400-1582329599@immunologisk-selskab.dk
SUMMARY:OPTIMMUNIZE: IMPROVING THE BENEFICIAL EFFECTS OF VACCINES
DESCRIPTION:19 – 21 February 2020 \nWellcome Genome Campus\, UK \nThe conference will explore and discuss various aspects of the non-specific effects of vaccines\, including their impact on neonates and infants\, how generalisable and durable these effects are\, the implications for geriatric and veterinary medicine\, and why non-specific effects should differ between sexes and across the lifespan. \nFor more information: Optimmunize_2019_A4_Poster \nAnd: Conference website
URL:https://immunologisk-selskab.dk/calendar/optimmunize-improving-the-beneficial-effects-of-vaccines/
LOCATION:Wellcome Genome Campus\, UK
CATEGORIES:Konferencer,News Items
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Copenhagen:20191209T100000
DTEND;TZID=Europe/Copenhagen:20191209T230000
DTSTAMP:20260815T174359
CREATED:20191114T135838Z
LAST-MODIFIED:20191206T075510Z
UID:5648-1575885600-1575932400@immunologisk-selskab.dk
SUMMARY:Immunology seminar by Valentyn Oksenych: New factors required for lymphocyte development: in vivo models
DESCRIPTION:On Monday\, December 9th\, Søren Degn will host a seminar given by Valentyn Oksenych\, PhD\, \ngroup leader at Department of Clinical and Molecular Medicine\, Norwegian University of Science and Technology (NTNU)\, Trondheim\, Norway. \nThe title of this I&I International Seminar is: \n  \n“New factors required for lymphocyte development: in vivo models” \n  \nVenue: Merete Barker Auditorium\, (Bldg. 1253-211 / Lake side lecture theatres) \n  \nTime: 10:00-11:00am \n  \nAbstract: \nDevelopment of B and T lymphocytes depends on the DNA breaks and repair events known as V(D)J recombination. There are two molecular pathways involved in the DNA repair during the lymphocyte development\, non-homologous end joining (NHEJ) and DNA damage response (DDR). Recently\, new accessory NHEJ factors PAXX and Mri were reported. Deficiency for PAXX or Mri\, however\, had no obvious effect on the lymphocyte development. Applying genetic models\, we found that PAXX and Mri are functionally redundant with another NHEJ factor\, XLF. Moreover\, combined deficiency for XLF/PAXX and XLF/Mri results in dramatic\, although distinct\, phenotypes. In addition\, we found that multiple factors from the DDR pathway are required for specific stages of B cell development.
URL:https://immunologisk-selskab.dk/calendar/immunology-seminar-by-valentyn-oksenych-new-factors-required-for-lymphocyte-development-in-vivo-models/
LOCATION:The Lakeside Auditoria\, Aarhus University\, Bartholins Alle 3\, Århus\, 8000\, Denmark
CATEGORIES:News Items
END:VEVENT
END:VCALENDAR